Rixensart, Walloon Region, be Management Occupations
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Job purpose : Within the Analytical Development Department, the Molecular Analytics Platform is in charge of developing modern, state-of-the-art molecular methods to detect, quantify and characterize nucleic acids at all stages of vaccines development. The hired Scientist will be in charge of implementing, designing and developing methods for the detection and quantification of nucleic acids based on up-to-date nucleic acid technologies (NAT) and, in particular, Next Generation Sequencing (NGS) assays. Expertise in performing NGS assays (short reads and long reads sequencing) is a must. Ability to do bioinformatics analysis with standard commercially available softwares is a clear asset, being able to interact with R and the Linux environment will be considered an added value. The candidate will be in charge of the design and development of NAT-based analytical methods to support product and process development, to develop and transfer release methods for GMP testing for Phase 1, Phase 2 and Phase 3, according to Quality by Design principles and in partnership with Technical Research and Development functions, Quality and Regulatory.
You contribute to the technical and technological developments ongoing in the group.
You work on the bench in the labs (> 60%).
You interact with Belgium- and US-based team members.
You contribute to the development and deployment of new genetic characterization technologies based on NGS platforms.
You ensure bioinformatic analysis of the NGS data produced within the group.
You ensure the development of alternative analytical methods (including alternatives to current DNA quantification methods) – including new purity testing, identity testing and SNP detection using state-of-the-art technologies (inlcuding probe-based detection techniques).
You interact and act in a complex matrix with several stakeholders from different departments (Research, Development, QC, RA, QA).
You interact with other GSK Vaccines RDC (US and IT) and external CMOs.
You ensure implementation of QbD (Quality by design) in the development of assays.
You are agile principles driven.
You have good writing skills and fluent in French and English.
You contribute to the various activities of the group.
You ensure that SOP are applied and respected.
You ensure that security rules are followed.
We are looking for professionals with these required skills to achieve our goals:
Master degree (Biotechnology, Molecular Biology, Biochemistry, ...) or equivalent by experience.
Junior – less than 5 years of experience.
Diversified expertise in molecular biology (diversity of techniques and technologies as well as diversity of subjects) – Sequencing technologies, ddPCR, QPCR, primer/probe design, nucleic acid sizing, etc.
Specific knowledge: purification and quantification of nucleic acids by different methods; deep expertise in sequencing (high throughput/short reads and long reads sequencing); team management.
Languages: Active French and English.
Software: Excel, Word, Powerpoint, CLC Genomics Workbench/Geneious or equivalent.
Good knowledge of bioinformatics.
If you have the following characteristics it would be a plus:
Good writing skills.
Nucleic acid extraction (experience with magnetic beads based technologies and automated extractors).
Sanger and high throughput sequencing technologies.
PCR, QPCR and ddPCR.
Design of primers and probes using recognized softwares, design of LNA-containing primers and probes, design probes for multiplex assays, design of taqman probes, ...